Evident Exception in Clinical Practice Not Sufficient to Break Traditional Hypothesis

Evident Exception in Clinical Practice Not Sufficient to Break Traditional Hypothesis

David Oaks I would like to thank PLoS Medicine for publishing Lacasse and Leo’s important and methodical Essay that debunks the “chemical imbalance” advertisements for psychiatric drugs [1]. Why would the United States Food and Drug Administration (FDA) approve such ads? Our human rights group, MindFreedom International, has been asking that question for a long time. On behalf of MindFreedom, U...

Sufficient trial size to inform clinical practice.

Medical research has evolved conventions for choosing sample size in randomized clinical trials that rest on the theory of hypothesis testing. Bayesian statisticians have argued that trials should be designed to maximize subjective expected utility in settings of clinical interest. This perspective is compelling given a credible prior distribution on treatment response, but there is rarely cons...

Tolerance Induced against a Novel Antigen Skin Inflammation Is Not Sufficient to Break

Patient-reported outcomes in clinical practice: using standards to break down barriers

While it seems obvious that medical care has always focused on the patient, recent efforts have been directed at formally integrating the patient’s ‘voice’ into clinical care. One of the main approaches for incorporating patient perspectives in clinical practice is the use of patient-reported outcomes (PROs) [1–3]. PROs are defined by the US FDA as “any report of the status of a patient’s healt...

Clinical supervision for allied health staff: necessary but not sufficient.

Objectives The aim of the present study was to explore the perspectives of allied health professionals on appropriate content for effective clinical supervision of staff. Methods A set of statements regarding clinical supervision was identified from the literature and confirmed through a Q-sort process. The final set was administered as an online survey to 437 allied health professionals workin...